Activase package insert pdf

Lactation there are no data on presence of activase package insert in human milk, effects on inssrt infant, or on milk production. It produces limited conversion of plasminogen in the absence of fibrin. Cathflo activase alteplase for injection is a sterile, white to pale yellow, lyophilized powder for intracatheter instillation for restoration of function to central venous access devices following reconstitution with sterile water for injection, usp. It is synthesized using the complementary dna cdna for natural human tissue. Also, prepare a polyvinyl chloride bag or glass vial along with an infusion set. Highlights of prescribing information acute ischemic. What is the fdaapproved indication for activase in stroke. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment.

Labetalol hcl has the empirical formula c 19 h 24 n 2 o 3 hcl and a molecular weight of 364. When introduced into the systemic circulation at pharmacologic concentration, activase binds to fibrin in a thrombus and converts the entrapped. Activase is an enzyme serine protease which has the property of fibrinenhanced conversion of plasminogen to plasmin. Monitor patients treated with cathflo activase for signs of hypersensitivity and. For this purpose a transfer cannula is included with the pack sizes of 20 mg and. Rabies vaccine rx only imovax rabies rabies is transmitted.

Intracameral tissue plasminogen activator use in a large. Please see full prescribing information for additional important safety information. Cathflo activase should be used with caution in the presence of known or suspected infection in the catheter. Activase is a sterile, white to offwhite, lyophilized powder for intravenous administration after reconstitution with sterile water for injection, usp. We did not include international guidelines or other international governmental restrictions on the use of alteplase because it. Reconstitute activase immediately before administration. Reconstitute 100 mg vial with 100 ml sterile water provided, see package insert for detailed instructions. Label alteplase activase, genentech, incorporated amazon s3. See tnkase package insert for instructions on the use of the dual cannula device. Indications activase alteplase is indicated for the treatment of acute. Activase alteplase for injection, for intravenous use.

Alteplase is an enzyme that has the property of fibrinenhanced conversion of plasminogen. Remove the shield assembly from the supplied bd 10 ml syringe with. Alteplase cathflo activase, genentech, package insert fda. Pasteur sa is a sterile, stable, freezedried suspension of. Ceftaroline package insert pdf download to reduce the development of drugresistant bacteria and maintain the effectiveness of teflaro and. Intracameral tissue plasminogen activator use in a large series of eyes with valved glaucoma drainage implants. Administration fda package insert, specifically for the only tissuetype plasminogen activator licensed for use in acute ischemic stroke, alteplase. Consult package insert for complete instructions on medication preparation, reconstitution and administration. Do not remove the vial adapter from the package or touch the inside of the package of the adapter. Please see accompanying full prescribing information for additional. Plasmin degrades the fibrin matrix of the thrombus, exerting its thrombolytic action. Australian product information actilyse alteplase powder for injection 1 name of the medicine alteplase rch 2 and 3 qualitative and quantitative composition and pharmaceutical form actilyse is presented as a sterile, white to offwhite, lyophilised powder, intended for intravenous.

Remove protective caps and swab the top of each vial with an alcohol wipe to reduce the risk of contamination. Actilyse 50 mg alteplase is used to treat various conditions caused by blood clots such as myocardial infarction, pulmonary embolism, and stroke. Management of acute ischemic stroke in adults, for improving neurological recovery, and reducing the incidence of disability approval date. Activase alteplase in acute ischemic stroke american heart. Remove the protective cap from one end of the transfer device and keeping the vial of sw upright, insert the piercing pin vertically into the center of the stopper of the vial of sw first. Thank you to all who responded to my post and for the helpful information about how other practices manage cathflo activase for their central lines. Powder for reconstitution for use in central venous access.

Using 2 additional 3ml syringes, withdraw normal saline equal to the remaining. Objectiveto describe the efficacy and complications of intracameral tissue plasminogen activator tpa in a large series of glaucomatous eyes with valved glauco. Begin by assembling the 50mg vial of activase, the vial of swfi usp, included with the activase package, a 50ml syringe, a largebore needle eg, 18gauge, and alcohol wipes. Remove the protective cap from the other end of the transfer device. Inside the alteplase package, you should find one vial of 100 ml of preservativefree sterile water for injection, one vial of 100 mg of alteplase, and the transfer device. Reconstitute retavase only with the supplied sterile water for injection. Activase alteplase is indicated for the treatment of acute ischemic stroke ais. Hypersensitivity hypersensitivity, including urticaria, angioedema and anaphylaxis, has been reported in association with use of cathflo activase.

With the vial sitting on a flat surface, insert the tip of the syringe into the adapter. Remove one of the protective caps from the transfer device and insert the. Appendix 4 alteplase use in hemodialysis central venous catheters contd intravenous infusion alteplase lock a. Cathflo activase alteplase is indicated for restoration of function to clotted central venous access devises as assessed by the inability to withdraw blood. Initiate treatment as soon as possible but within 3 hours after symptom onset. These highlights do not include all the information needed to use. Indications activase alteplase is indicated for the treatment of acute ischemic stroke. Lippincott nursingcenter nursing pocket card alteplase.

Insert the exposed end all the way through the center of. Appendix alteplase use in hemodialysis central venous. It is a sterile, purified glycoprotein of 527 amino acids. Dailymed cathflo activase alteplase injection, powder.

A study of another alteplase product, actilyse, in acute ischemic stroke. Contraindications cathflo activase should not be administered to patients with known hypersensitivity to alteplase or any component of the formulation. It has two asymmetric centers and therefore exists as a molecular complex of two diastereoisomeric pairs. Carefully lower blood pressure bp to maintain systolic bp rtpa. Frequently asked questions about activase alteplase in acute ischemic stroke. Alteplase tpathrombolysis for acute stroke dosing chart concentration. Biological potency is determined by an in vitro clot lysis assay and is expressed in international units as tested against the who standard. First next 60 minutes first over 1 minute over 1 minute next 60 minutes. Remove the protective cap from one end of the transfer device and keeping the vial of swfi upright, insert the piercing pin vertically into the center of the stopper of the vial of swfi. The activase package insert you have selected will take you away from this site to one that is not owned or controlled by genentech, inc. Cathflo activase alteplase 2 cathflo activase 3 alteplase 4 powder for reconstitution for use in central venous access 5 devices 6 description 7 cathflo activase alteplase is a tissue plasminogen activator tpa 8 produced by recombinant dna technology.